Xiong, Xiang Yuan and Li, Yu Ping and Li, Zi Ling and Zhou, Chun Li and Tam, Kam Chiu and Liu, Zhi Yong and Xie, Guo Xiu (2007) Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery. Journal of Controlled Release, 120 (1-2). 11 - 17.
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Official URL: http://www.sciencedirect.com/science/article/B6T3D...
Abstract
The morphologies of poly(lactic acid)-b-Pluronic-b-poly(lactic acid) (PLA-F127-PLA) aggregates in aqueous solutions were reported previously to be vesicular nano-particles by our group. In the present study, we seek to investigate the feasibility of using PLA-F127-PLA vesicles as oral delivery carrier for insulin. Both in vitro and in vivo release behavior of insulin loaded in PLA-F127-PLA vesicles were studied. A biphasic release behavior was observed for the in vitro release of insulin from PLAF127-29 vesicles. More importantly, it was found in the diabetic mice tests that the blood glucose concentration of oral insulin-loaded PLAF127-29 vesicles decreased from 18.5 to 5.3 mmol/L within 4.5 h and the minimum blood glucose concentration (about 4.5 mmol/L) was achieved after about 5 h. Furthermore, the blood glucose concentration was maintained at this level for at least an additional 18.5 h. These results proved that PLA-F127-PLA vesicles could be promising polymeric carriers for oral insulin delivery application due to their prolonged hypoglycemic effect.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLA-F127-PLA block copolymer; Biocompatible; Vesicles; Insulin; Oral delivery |
| Subjects: | Biomedical Science > Nanomedicine |
| ID Code: | 5714 |
| Deposited By: | SPI |
| Deposited On: | 27 Jul 2009 10:37 |
| Last Modified: | 27 Jul 2009 10:37 |
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