Crisante, Fernanda and Francolini, Iolanda and Bellusci, Mariangela and Martinelli, Andrea and D'Ilario, Lucio and Piozzi, Antonella (2009) Antibiotic delivery polyurethanes containing albumin and polyallylamine nanoparticles. European Journal of Pharmaceutical Sciences, 36 (4-5). 555 - 564.
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Official URL: http://www.sciencedirect.com/science/article/B6T25...
Nano-structured polymers delivering an antibiotic for the prevention of medical device-related infections were developed. Systems consisted of bovine serum albumin or polyallylamine nanoparticles alone or entrapped in a polyurethane and then loaded with cefamandole nafate, chosen as a drug model. Results showed that nanoparticles alone were able to adsorb high antibiotic amounts due to their high surface/volume ratio. However, they released cefamandole in an uncontrolled fashion, leading to a rapid loss of antibacterial activity. Improvements in the release control were obtained when CEF loaded and non-loaded nanoparticles were entrapped in a carboxylated polyurethane. For these systems the drug delivery was at least of 50% with respect to nanoparticles alone with a prolonged antimicrobial activity up to 9 days.
|Uncontrolled Keywords:||Antibiotic delivery; Nanoparticles; Polyurethanes; Albumin; Polyallylamine|
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited On:||28 Jul 2009 14:41|
|Last Modified:||28 Jul 2009 14:41|
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