Wu, Ming and Kleiner, Lothar and Tang, Fuh-Wei and Hossainy, Syed and Davies, Martyn C. and Roberts, Clive J. (2009) Nanoscale mechanical measurement determination of the glass transition temperature of poly(lactic acid)/everolimus coated stents in air and dissolution media. European Journal of Pharmaceutical Sciences, 36 (4-5). 493 - 501.
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Official URL: http://www.sciencedirect.com/science/article/B6T25...
Abstract
Localized atomic force microscopy (AFM) force analysis on poly(lactic acid) (PLA) and poly(lactic acid)/everolimus coated stents has been performed under ambient conditions. Similar Young's modulus were derived from both PLA and PLA/everolimus stent surface, namely 2.25 ± 0.46 and 2.04 ± 0.39 GPa, respectively, indicating that the drug, everolimus does not significantly effect the mechanical properties of PLA up to a 1:1 (w/w) drug loading. Temperature controlled force measurements on PLA only coated stents in air and in a 1% Triton surfactant solution allowed the glass transition temperature (Tg) of the polymer to be determined. A significant drop of the Young's modulus in solution was observed at 36 °C, suggests that in vivo the Tg of the polymer is below body temperature. The possible consequences on drug release and the mechanisms by which this may occur are considered.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AFM; Polylactic acid; Nano-indentation; Glass transition temperature |
| Subjects: | Biomedical Science > Nanomedicine |
| ID Code: | 5697 |
| Deposited By: | SPI |
| Deposited On: | 28 Jul 2009 14:44 |
| Last Modified: | 28 Jul 2009 14:44 |
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