Nano Archive

A simple route to prepare stable hydroxyapatite nanoparticles suspension

Han, Yingchao and Wang, Xinyu and Li, Shipu (2009) A simple route to prepare stable hydroxyapatite nanoparticles suspension. Journal of Nanoparticle Research, 11 (5). pp. 1235-1240.


Official URL:


A simple ultrasound assisted precipitation method with addition of glycosaminoglycans (GAGs) is proposed to prepare stable hydroxyapatite (HAP) nanoparticles suspension from the mixture of Ca(H2PO4)2 solution and Ca(OH)2 solution. The product was characterized by XRD, FT-IR, TEM, HRTEM and particle size, and zeta potential analyzer. TEM observation shows that the suspension is composed of 10–20 nm × 20–50 nm short rod-like and 10–30 nm similar spherical HAP nanoparticles. The number-averaged particle size of stable suspension is about 30 nm between 11.6 and 110.5 nm and the zeta potential is −60.9 mV. The increase of stability of HAP nanoparticles suspension mainly depends on the electrostatic effect and steric effect of GAGs. The HAP nanoparticles can be easily transported into the cancer cells and exhibit good potential as gene or drug carrier system.

Item Type:Article
Subjects:Material Science > Nanofabrication processes and tools
Physical Science > Nano objects
Biomedical Science > Nanomedicine
ID Code:5588
Deposited By:IoN
Deposited On:29 Jun 2009 15:13
Last Modified:29 Jun 2009 15:13

Repository Staff Only: item control page