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A Novel Approach to Molecular Recognition Surface of Magnetic Nanoparticles Based on Host-Guest Effect

Wu, Yuanpeng and Zuo, Fang and Zheng, Zhaohui and Ding, Xiaobin and Peng, Yuxing (2009) A Novel Approach to Molecular Recognition Surface of Magnetic Nanoparticles Based on Host-Guest Effect. Nanoscale Research Letters, 4 (7). pp. 738-747.

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Official URL: http://www.springerlink.com/content/u5v26004340187...

Abstract

A novel route has been developed to prepared β-cyclodextrin (β-CD) functionalized magnetic nanoparticles (MNPs). The MNPs were first modified with monotosyl-poly(ethylene glycol) (PEG) silane and then tosyl units were displaced by amino-β-CD through the nucleophilic substitution reaction. The monotosyl-PEG silane was synthesized by modifying a PEG diol to form the corresponding monotosyl-PEG, followed by a reaction with 3-isocyanatopropyltriethoxysilane (IPTS). The success of the synthesis of the monotosyl-PEG silane was confirmed with 1H NMR and Fourier transform infrared (FTIR) spectroscopy. The analysis of FTIR spectroscopy and X-ray photoelectron spectroscopy (XPS) confirmed the immobilization of β-CD onto MNPs. Transmission electron microscopy (TEM) indicated that the β-CD functionalized MNPs were mostly present as individual nonclustered units in water. The number of β-CD molecules immobilized on each MNP was about 240 according to the thermogravimetric analysis (TGA) results. The as-prepared β-CD functionalized MNPs were used to detect dopamine with the assistance of a magnet.

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Physical Science > Nanomagnetics
Material Science > Nanochemistry
Biomedical Science > Nanomedicine
ID Code:5533
Deposited By:IoN
Deposited On:30 Jun 2009 11:53
Last Modified:30 Jun 2009 11:53

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