Nano Archive

Amphiphilic poly-N-vinylpyrrolidone nanocarriers with incorporated model proteins

Kuskov, A N and Villemson, A L and Shtilman, M I and Larionova, N I and Tsatsakis, A M and Tsikalas, I and Rizos, A K (2007) Amphiphilic poly-N-vinylpyrrolidone nanocarriers with incorporated model proteins. Journal of Physics: Condensed Matter, 19 (20). 205139 (11pp).

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New nanoscaled polymeric carriers have been prepared on the basis of different amphiphilic water-soluble derivatives of poly-N-vinylpyrrolidone (PVP). The polymer self-assembly and interaction with model proteins (Bowman-Birk soybean proteinase inhibitor (BBI) and its hydrophobized derivatives) were studied in aqueous media. The possibility of inclusion of both BBI and hydrophobized oleic acid derivatives of BBI in amphiphilic PVP aggregates was investigated. It was ascertained that polymeric particles of size 50-80 nm were formed in certain concentrations of amphiphilic PVP and poorly soluble dioleic acid derivatives of BBI. Such polymeric aggregates are capable of solubilization of dioleoyl BBI with a concomitant prevention of its inactivation at low pH values.

Item Type:Article
ID Code:5326
Deposited By:Prof. Alexey Ivanov
Deposited On:06 Aug 2009 11:25
Last Modified:06 Aug 2009 11:32

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