Takei, Kuniharu and Kawashima, Takahiro and Kawano, Takeshi and Kaneko, Hidekazu and Sawada, Kazuaki and Ishida, Makoto (2009) Out-of-plane microtube arrays for drug delivery-liquid flow properties and an application to the nerve block test. Biomedical Microdevices, 11 (3). pp. 539-545.
We have proposed fabricating very fine out-of-plane silicon-dioxide microtube arrays using a selective vapor liquid solid (VLS) growth technique and microfabrication processes. In this study, we elucidated the liquid-flow properties of microtubes with different inner diameters. Our fabricated microtubes were 0.5 mu m in wall thickness; 20 mu m in height; and either 2.5 mu m, 4.1mu m, 4.6mu m, or 6.4mu m in inner diameter. We determined the relationship between the flow pressure and the liquid flow rate through the microtube. We also conducted a nerve block test, in which a microtube with 4.6mu m inner diameter was used to administer lidocaine solution (Na channel blocker) to the rat sciatic nerve. This successful test represents the first reported use of a microtube for drug delivery to the peripheral nerve of a rat. We conclude that the proposed microtube array and its fabrication process might contribute to developing pharmacological devices.
|Subjects:||Engineering > Nanotechnology applications in mechanical engineering|
|Deposited On:||25 Aug 2010 07:57|
|Last Modified:||25 Aug 2010 07:57|
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