Pereira, Rosa and Julianto, Tommy and Yuen, Kah Hay and Abu Bakar, Abdul Majeed (2006) Anionic Eudragit nanoparticles as carriers for oral administration of peptidomimetic drugs. School of Pharmacy, Universiti Sains Malaysia, Penang, Malaysia. .
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Abstract
Nanoparticles made of anionic Eudragit (L100, L100-55 and S100) were obtained by a novel pH-nanoprecipitation method. In order to stabilize the resulting nanosuspensions, different stabilizers were added, and their effect on the size, zeta potential, drug entrapment and nanoparticle recovery were evaluated. Even though nanoparticles without stabilizers are effective at increasing the peptidomimetic drug (using cefotaxime sodium as model) peroral absorption, the addition of stabilizers prevents coalescence of nanoparticles and lead to better incorporation efficiencies, as well as a final acceptable nanoparticle yield
| Item Type: | Article |
|---|---|
| Subjects: | Material Science > Nanostructured materials |
| ID Code: | 5025 |
| Deposited By: | CSMNT |
| Deposited On: | 20 Apr 2009 11:07 |
| Last Modified: | 12 Aug 2009 12:17 |
Available Versions of this Item
- Anionic Eudragit nanoparticles as carriers for oral administration of peptidomimetic drugs. (deposited 13 Jan 2009 10:32)
- Anionic Eudragit nanoparticles as carriers for oral administration of peptidomimetic drugs. (deposited 20 Apr 2009 11:07) [Currently Displayed]
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