Ciofani, Gianni and Raffa, Vittoria and Menciassi, Arianna and Dario, Paolo (2008) Alginate and chitosan particles as drug delivery system for cell therapy. BIOMEDICAL MICRODEVICES, 10 (2). pp. 131-140.
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Official URL: http://www.springerlink.com/content/038381q173x6jq...
Drug-carrying microstructures which have a size similar to biological structures are very attractive to encapsulate drugs and protect them during the transit in the human body. This paper describes polymeric (alginate and chitosan) particles (average radius 500 nm) produced by homogenization techniques. In vitro studies performed on cell lines demonstrate the effectiveness of such particles for intracellular drug delivery. Our experiments suggest that cellular up - take increases linearly with particle concentration in the growth medium, and the internalization process has a first order kinetics (characteristic time around 0.5 h(-1)). In addition, the particles degrade within 24 h from the up-take without side effects for cell viability.
|Uncontrolled Keywords:||drug delivery system; alginate particles; chitosan particles; cellular up-take|
|Subjects:||Biomedical Science > Nanobiotechnology|
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
|Deposited By:||INVALID USER|
|Deposited On:||04 Dec 2008 13:19|
|Last Modified:||04 Dec 2008 13:19|
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