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A super highly sensitive glucose biosensor based on Au nanoparticles-AgCl@polyaniline hybrid material

Yan, Wei and Feng, Xiaomiao and Chen, Xiaojun and Hou, Wenhua and Zhu, Jun-Jie (2008) A super highly sensitive glucose biosensor based on Au nanoparticles-AgCl@polyaniline hybrid material. BIOSENSORS & BIOELECTRONICS, 23 (7). pp. 925-931.

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Gold nanoparticles (AuNPs) with an average diameter of 5 nm were assembled on the surface of silver chloride@polyaniline (PANI) core-shell nanocomposites (AgCl@PANI). Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) suggested that AuNPs were incorporated on AgCl@PANI through coordination bonds instead of electrostatic interaction. The resulting AuNPs-AgCl@PANI hybrid material exhibited good electroactivity at a neutral pH environment. An amperometric glucose biosensor was developed by adsorption of glucose oxidase (GOx) on an AuNPs-AgCl@PANI modified glassy carbon (GC) electrode. AuNPs-AgCl@PANI could provide a biocompatible surface for high enzyme loading. Due to size effect, the AuNPs in the hybrid material could act as a good catalyst for both oxidation and reduction of H2O2. As the measurement of glucose was based on the electrochemical detection of H2O2 generated by enzyme-catalyzed-oxidation of glucose, the biosensor exhibited a super highly sensitive response to the analyte with a detection limit of 4 pM. Moreover, the biosensor showed good reproducibility and operation stability. The effects of some factors, such as temperature and pH value, were also studied. (C) 2007 Elsevier B.V. All rights reserved.

Item Type:Article
Uncontrolled Keywords:glucose biosensor; AgCl@polyaniline core-shell nanocomposite; Au nanoparticles; differential pulse voltammetry
Subjects:Material Science > Nanofabrication processes and tools
Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
ID Code:500
Deposited On:04 Dec 2008 13:22
Last Modified:04 Dec 2008 13:22

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