Yan, Wei and Feng, Xiaomiao and Chen, Xiaojun and Hou, Wenhua and Zhu, Jun-Jie (2008) A super highly sensitive glucose biosensor based on Au nanoparticles-AgCl@polyaniline hybrid material. BIOSENSORS & BIOELECTRONICS, 23 (7). pp. 925-931.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Gold nanoparticles (AuNPs) with an average diameter of 5 nm were assembled on the surface of silver chloride@polyaniline (PANI) core-shell nanocomposites (AgCl@PANI). Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) suggested that AuNPs were incorporated on AgCl@PANI through coordination bonds instead of electrostatic interaction. The resulting AuNPs-AgCl@PANI hybrid material exhibited good electroactivity at a neutral pH environment. An amperometric glucose biosensor was developed by adsorption of glucose oxidase (GOx) on an AuNPs-AgCl@PANI modified glassy carbon (GC) electrode. AuNPs-AgCl@PANI could provide a biocompatible surface for high enzyme loading. Due to size effect, the AuNPs in the hybrid material could act as a good catalyst for both oxidation and reduction of H2O2. As the measurement of glucose was based on the electrochemical detection of H2O2 generated by enzyme-catalyzed-oxidation of glucose, the biosensor exhibited a super highly sensitive response to the analyte with a detection limit of 4 pM. Moreover, the biosensor showed good reproducibility and operation stability. The effects of some factors, such as temperature and pH value, were also studied. (C) 2007 Elsevier B.V. All rights reserved.
|Uncontrolled Keywords:||glucose biosensor; AgCl@polyaniline core-shell nanocomposite; Au nanoparticles; differential pulse voltammetry|
|Subjects:||Material Science > Nanofabrication processes and tools|
Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
|Deposited By:||INVALID USER|
|Deposited On:||04 Dec 2008 13:22|
|Last Modified:||04 Dec 2008 13:22|
Repository Staff Only: item control page