Nisisako, Takasi and Torii, T. (2008) Microfluidic large-scale integration on a chip for mass production of monodisperse droplets and particles. LAB ON A CHIP, 8 (2). pp. 287-293.
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In this study, we report the mass production of monodisperse emulsion droplets and particles using microfluidic large-scale integration on a chip. The production module comprises a glass microfluidic chip with planar microfabricated 16-256 droplet-formation units (DFUs) and a palm-sized stainless steel holder having several layers for supplying liquids into the inlets of the mounted chip. By using a module having 128 cross-junctions (i.e., 256 DFUs) arranged circularly on a 4 cm 6 4 cm chip, we could produce droplets of photopolymerizable acrylate monomer at a throughput of 320.0 mL h(-1). The product was monodisperse, having a mean diameter of 96.4 mm, with a coefficient of variation (CV) of 1.3%. Subsequent UV polymerization off the module yielded monodisperse acrylic microspheres at a throughput of similar to 0.3 kg h(-1). Another module having 128 co-flow geometries could produce biphasic Janus droplets of black and white segments at 128.0 mL h(-1). The product had a mean diameter of 142.3 mm, with a CV of 3.3%. This co-flow module could also be applied in the mass production of homogeneous monomer droplets.
|Subjects:||Material Science > Nanofabrication processes and tools|
Material Science > Nanochemistry
|Deposited By:||INVALID USER|
|Deposited On:||04 Dec 2008 15:47|
|Last Modified:||05 Jan 2009 17:23|
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