Nano Archive

Anionic Eudragit nanoparticles as carriers for oral administration of peptidomimetic drugs

Pereira, Rosa and Julianto, Tommy and Yuen, Kah Hay and Majeed, Abu Bakar Abdul (2006) Anionic Eudragit nanoparticles as carriers for oral administration of peptidomimetic drugs. Nano-Optoelectronics Research and Technology .

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Abstract

Nanoparticles made of anionic Eudragit(L100, L100-55 and S100) were obtained by a novel pHnanoprecipitation method. In order to stabilize the resulting nanosuspensions, different stabilizers were added, and their effect on the size, zeta potential, drug entrapment and nanoparticle recovery were evaluated. Even though nanoparticles without stabilizers are effective at increasing the peptidomimetic drug (using cefotaxime sodium as model) peroral absorption, the addition of stabilizers prevents coalescence of nanoparticles and lead to better incorporation efficiencies, as well as a final acceptable nanoparticle yield.

Item Type:Article
Subjects:Material Science > Nanostructured materials
ID Code:4566
Deposited By:CSMNT
Deposited On:08 Apr 2009 03:15
Last Modified:08 Apr 2009 03:15

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