Nano Archive

Preparation and characterization of smart polymer brush-modified magnetic nanoparticles for biomedicine application

Wang, Shixing and Zhou, Yang and Guan, Wen and Ding, Bingjun (2009) Preparation and characterization of smart polymer brush-modified magnetic nanoparticles for biomedicine application. Journal of Nanoparticle Research, 11 (4). pp. 909-916.

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Official URL: http://www.springerlink.com/content/yt4634xp544330...

Abstract

This paper investigates synthesis and characterization of smart polymer brush-modified magnetic nanoparticles (SPB-MNPs). Magnetic nanoparticles (MNPs) modified with poly(poly(ethylene glycol) monomethacrylate (poly(PEGMA)) brush were first functioned with activated pyridyldithio. Then, MNPs functioned with pyridyldithio (MNPs-PEG-PDT) were conjugated with 4-diamino-6-mercaptopyrimidine (DMP) to form SPB-MNPs via stimuli-responsive disulfide linkage. Fourier transform infrared spectra (FTIR) was used to monitor the preparation process of MNPs-PEG-PDT. MNPs-PEG-PDT is very highly reactive toward DMP. The disulfide linkage of SPB-MNPs can be cleaved by reduced glutathione (GHS). The concentration of GHS plays an important role in controlling the cleaved efficiency. The optimum concentration of GHS to release DMP is in the millimolar range.

Item Type:Article
ID Code:4523
Deposited By:Prof. Alexey Ivanov
Deposited On:08 May 2009 06:18
Last Modified:08 May 2009 09:53

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