Nano Archive

Hydrophobic polymers modification of mesoporous silica with large pore size for drug release

Zhu, Shenmin and Zhang, Di and Yang, Na (2009) Hydrophobic polymers modification of mesoporous silica with large pore size for drug release. Journal of Nanoparticle Research, 11 (3). pp. 561-568.

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Official URL: http://www.springerlink.com/content/06481k25007325...

Abstract

Mesostructure cellular foam (MCF) materials were modified with hydrophobic polyisoprene (PI) through free radical polymerization in the pores network, and the resulting materials (MCF-PI) were investigated as matrices for drug storage. The successful synthesis of PI inside MCF was characterized by Fourier transform infrared (FT-IR), hydrogen nuclear magnetic resonance (1H NMR), X-ray diffraction patterns (XRD) and nitrogen adsorption/desorption measurements. It was interesting to find the resultant system held a relatively large pore size (19.5 nm) and pore volume (1.02 cm3 g−1), which would benefit for drug storage. Ibuprofen (IBU) and vancomycin were selected as model drugs and loaded onto unmodified MCF and modified MCF (MCF-PI). The adsorption capacities of these model drugs on MCF-PI were observed increase as compared to that of on pure MCF, due to the trap effects induced by polyisoprene chains inside the pores. The delivery system of MCF-PI was found to be more favorable for the adsorption of IBU (31 wt%, IBU/silica), possibly attributing to the hydrophobic interaction between IBU and PI formed on the internal surface of MCF matrix. The release of drug through the porous network was investigated by measuring uptake and release of IBU.

Item Type:Article
ID Code:4250
Deposited By:Prof. Alexey Ivanov
Deposited On:16 Mar 2009 09:42
Last Modified:08 May 2009 23:31

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