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pH-Sensitive Micelles Based on Double-Hydrophilic Poly(methylacrylic acid)-Poly(ethylene glycol)-Poly(methylacrylic acid) Triblock Copolymer

Tao, Youhua and Liu, Ren and Liu, Xiaoya and Chen, Mingqing and Yang, Cheng and Ni, Zhongbin (2009) pH-Sensitive Micelles Based on Double-Hydrophilic Poly(methylacrylic acid)-Poly(ethylene glycol)-Poly(methylacrylic acid) Triblock Copolymer. Nanoscale Research Letters, 4 (4). pp. 341-343. ISSN 1931-7573 (Print) 1556-276X (Online)

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Abstract

pH-sensitive micelles with hydrophilic core and hydrophilic corona were fabricated by self-assembling of triblock copolymer of poly(methylacrylic acid)-poly(ethylene glycol)-poly(methylacrylic acid) at lower solution pH. Transmission electron microscopy and laser light scattering studies showed micelles were in nano-scale with narrow size distribution. Solution pH value and the micelles concentration strongly influenced the hydrodynamic radius of the spherical micelles (48–310 nm). A possible mechanism for the formation of micelles was proposed. The obtained polymeric micelle should be useful for biomedical materials such as carrier of hydrophilic drug

Item Type:Article
Uncontrolled Keywords:Self-assembly - Micelles - Double-hydrophilic - Triblock copolymers
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:4145
Deposited By:Lesley Tobin
Deposited On:02 Nov 2009 11:43
Last Modified:02 Nov 2009 11:43

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