Nano Archive

Nanomechanics of membrane tubulation and DNA assembly

Roopa, T and Shivashankar, G. V. (2003) Nanomechanics of membrane tubulation and DNA assembly. Applied Physics Letters, 82 . p. 1631.

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We report an interesting regime of tubule formation in multilamellar membrane vesicles. An optically trapped bead is used to apply a localized subpicoNewton force on a cationic vesicle to form a membrane tubule. The force extension curves reveal a saturation phase, with the tubule length extending up to tens of microns, beyond a threshold force 0.6+/-0.2 pN. We then use the tubule as a sensor for monitoring the dynamics of charge induced DNA integration on cationic membrane vesicles. Our results may also have applications in the development of nanowires and nanofluidic devices.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Divisions:Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
ID Code:4079
Deposited By:JNCASR
Deposited On:02 Feb 2009 04:59
Last Modified:18 Apr 2009 09:14

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