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Fluorescence Methods to Probe Nanometer-Scale Organization of Molecules in Living Cell Membranes

Krishnan , R. V and Varma , R and Mayor , S (2001) Fluorescence Methods to Probe Nanometer-Scale Organization of Molecules in Living Cell Membranes. Journal of Fluorescence, 11 . pp. 211-226.

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Official URL: http://www.ingentaconnect.com/klu/jofl/2001/000000...

Abstract

The ability to study the structure and function of cell membranes and membrane components is fundamental to understanding cellular processes. This requires the use of methods which are capable of resolving structures at nanometer-scale resolution in living cells. In this review we survey fluorescence imaging methodologies capable of nanometer-scale resolution. We then critically examine specific biological applications of these methods, in the context of understanding membrane protein conformation and dynamics, intracellular signaling, organization of lipid rafts, and cell surface topology.

Item Type:Article
Subjects:Biomedical Science > Nanoscale biological processes
Divisions:Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
ID Code:4071
Deposited By:JNCASR
Deposited On:03 Apr 2009 05:34
Last Modified:09 Apr 2009 05:20

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