Nano Archive

A fluorescent nanosensor for apoptotic cells

Quinti, L and Weissleder, R and Tung, CH (2006) A fluorescent nanosensor for apoptotic cells. NANO LETTERS, 6 (3). pp. 488-490.

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Official URL: http://dx.doi.org/10.1021/nl0524694

Abstract

A biocompatible surface-functionalized nanoparticle was designed to sense phosphatidylserine exposed on apoptotic cells. We conjugated synthetic artificial phosphatidylserine binding ligands in a multivalent fashion onto magnetofluorescent nanoparticles. Our results show that (1) the synthetic nanoparticles bind to apoptotic cells, (2) there is excellent correlation with annexin V staining by microscopy, and (3) FACS analysis with nanoparticles allows the measurement of therapeutic apoptosis induction. The described nanomaterials should be useful for a variety of biomedical applications including in vivo imaging of apoptosis.

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
ID Code:3824
Deposited By:SPI
Deposited On:22 Jan 2009 09:32
Last Modified:22 Jan 2009 09:32

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