Quinti, L and Weissleder, R and Tung, CH (2006) A fluorescent nanosensor for apoptotic cells. NANO LETTERS, 6 (3). pp. 488-490.
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Official URL: http://dx.doi.org/10.1021/nl0524694
Abstract
A biocompatible surface-functionalized nanoparticle was designed to sense phosphatidylserine exposed on apoptotic cells. We conjugated synthetic artificial phosphatidylserine binding ligands in a multivalent fashion onto magnetofluorescent nanoparticles. Our results show that (1) the synthetic nanoparticles bind to apoptotic cells, (2) there is excellent correlation with annexin V staining by microscopy, and (3) FACS analysis with nanoparticles allows the measurement of therapeutic apoptosis induction. The described nanomaterials should be useful for a variety of biomedical applications including in vivo imaging of apoptosis.
| Item Type: | Article |
|---|---|
| Subjects: | Analytical Science > Nanotechnology for sensing and actuating |
| ID Code: | 3824 |
| Deposited By: | SPI |
| Deposited On: | 22 Jan 2009 09:32 |
| Last Modified: | 22 Jan 2009 09:32 |
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