Frias, Juan C. and Ma, Yanqing and Williams, Kevin Jon and Fayad, Zahi A. and Fisher, Edward A. (2006) Properties of a versatile nanoparticle platform contrast agent to image and characterize atherosclerotic plaques by magnetic resonance imaging. NANO LETTERS, 6 (10). pp. 2220-2224.
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Official URL: http://dx.doi.org/10.1021/nl061498r
The need for more specific and selective contrast agents for magnetic resonance imaging motivated us to prepare a new nanoparticle agent based on high-density lipoproteins (HDL). This second generation contrast agent can be prepared in three different ways. The HDL nanoparticles (rHDL) were fully characterized by FPLC and gel electrophoresis. The flexibility of the platform also allows us to incorporate optical probes into rHDL for localization ex vivo by confocal fluorescence microscopy. The contrast-agent-containing nanoparticles were injected into mice that develop atherosclerotic lesions. Magnetic resonance imaging of the animals showed clear enhancement of the atherosclerotic plaques.
|Subjects:||Analytical Science > Microscopy and probe methods|
Biomedical Science > Nanomedicine
|Deposited On:||22 Jan 2009 10:34|
|Last Modified:||22 Jan 2009 10:34|
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