Withey, GD and Lazareck, AD and Tzolov, MB and Yin, A and Aich, P and Yeh, JI and Xu, JM (2006) Ultra-high redox enzyme signal transduction using highly ordered carbon nanotube array electrodes. BIOSENSORS & BIOELECTRONICS, 21 (8). pp. 1560-1565.
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Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Abstract
We report on a highly ordered array of carbon nanotubes (CNTs) that serves as a universally direct nanoelectrode interface for redox proteins and provides an efficient conduit for electron transfer. The site-selective, covalent docking of the enzyme glucose oxidase (GO(x)) on the CNT tips is found to have a marked effect on enhancing electron transfer properties, as measured by cyclic voltammetry. A unimolecular electron transfer rate of 1500 s(-1) has been measured for this system, a value exceeding the rate of oxygen reduction by glucose oxidase. Furthermore, the redox enzyme-CNT array conjugate can be utilized as a quantitative, substrate-specific biosensor. (c) 2005 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | biosensors; carbon nanotube; highly ordered array; glucose oxidase; direct electron transfer |
| Subjects: | Analytical Science > Nanotechnology for sensing and actuating Biomedical Science > Nanobiotechnology Physical Science > Nanoelectronics |
| ID Code: | 3804 |
| Deposited By: | SPI |
| Deposited On: | 23 Jan 2009 10:30 |
| Last Modified: | 23 Jan 2009 10:30 |
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