Withey, GD and Lazareck, AD and Tzolov, MB and Yin, A and Aich, P and Yeh, JI and Xu, JM (2006) Ultra-high redox enzyme signal transduction using highly ordered carbon nanotube array electrodes. BIOSENSORS & BIOELECTRONICS, 21 (8). pp. 1560-1565.
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We report on a highly ordered array of carbon nanotubes (CNTs) that serves as a universally direct nanoelectrode interface for redox proteins and provides an efficient conduit for electron transfer. The site-selective, covalent docking of the enzyme glucose oxidase (GO(x)) on the CNT tips is found to have a marked effect on enhancing electron transfer properties, as measured by cyclic voltammetry. A unimolecular electron transfer rate of 1500 s(-1) has been measured for this system, a value exceeding the rate of oxygen reduction by glucose oxidase. Furthermore, the redox enzyme-CNT array conjugate can be utilized as a quantitative, substrate-specific biosensor. (c) 2005 Elsevier B.V. All rights reserved.
|Uncontrolled Keywords:||biosensors; carbon nanotube; highly ordered array; glucose oxidase; direct electron transfer|
|Subjects:||Analytical Science > Nanotechnology for sensing and actuating|
Biomedical Science > Nanobiotechnology
Physical Science > Nanoelectronics
|Deposited On:||23 Jan 2009 10:30|
|Last Modified:||23 Jan 2009 10:30|
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