Zhang, Yan and So, Min Kyung and Rao, Jianghong (2006) Protease-modulated cellular uptake of quantum dots. NANO LETTERS, 6 (9). pp. 1988-1992.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://dx.doi.org/10.1021/nl0611586
Quantum dots ( QDs) are often cell-impermeable and require transporters to facilitate crossing over cell membranes. Here we present a simple and versatile method that utilizes enzymes, matrix metalloprotease 2 ( MMP-2) and MMP-7, to modulate the cellular uptake of QDs. QD-peptide conjugates could be efficiently taken up into cells after the MMP treatment. This enzyme-modulated cellular uptake of QDs may be applied to other nanoparticles for biological imaging and selective drug delivery into tumor cells.
|Subjects:||Biomedical Science > Nanoscale biological processes|
Biomedical Science > Nanobiotechnology
Physical Science > Quantum phenomena
Biomedical Science > Nanomedicine
|Deposited On:||22 Jan 2009 11:45|
|Last Modified:||22 Jan 2009 11:45|
Repository Staff Only: item control page