Nano Archive

Protease-modulated cellular uptake of quantum dots

Zhang, Yan and So, Min Kyung and Rao, Jianghong (2006) Protease-modulated cellular uptake of quantum dots. NANO LETTERS, 6 (9). pp. 1988-1992.

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Official URL: http://dx.doi.org/10.1021/nl0611586

Abstract

Quantum dots ( QDs) are often cell-impermeable and require transporters to facilitate crossing over cell membranes. Here we present a simple and versatile method that utilizes enzymes, matrix metalloprotease 2 ( MMP-2) and MMP-7, to modulate the cellular uptake of QDs. QD-peptide conjugates could be efficiently taken up into cells after the MMP treatment. This enzyme-modulated cellular uptake of QDs may be applied to other nanoparticles for biological imaging and selective drug delivery into tumor cells.

Item Type:Article
Subjects:Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanobiotechnology
Physical Science > Quantum phenomena
Biomedical Science > Nanomedicine
ID Code:3786
Deposited By:SPI
Deposited On:22 Jan 2009 11:45
Last Modified:22 Jan 2009 11:45

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