Zhang, Yan and So, Min Kyung and Rao, Jianghong (2006) Protease-modulated cellular uptake of quantum dots. NANO LETTERS, 6 (9). pp. 1988-1992.
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Official URL: http://dx.doi.org/10.1021/nl0611586
Abstract
Quantum dots ( QDs) are often cell-impermeable and require transporters to facilitate crossing over cell membranes. Here we present a simple and versatile method that utilizes enzymes, matrix metalloprotease 2 ( MMP-2) and MMP-7, to modulate the cellular uptake of QDs. QD-peptide conjugates could be efficiently taken up into cells after the MMP treatment. This enzyme-modulated cellular uptake of QDs may be applied to other nanoparticles for biological imaging and selective drug delivery into tumor cells.
| Item Type: | Article |
|---|---|
| Subjects: | Biomedical Science > Nanoscale biological processes Biomedical Science > Nanobiotechnology Physical Science > Quantum phenomena Biomedical Science > Nanomedicine |
| ID Code: | 3786 |
| Deposited By: | SPI |
| Deposited On: | 22 Jan 2009 11:45 |
| Last Modified: | 22 Jan 2009 11:45 |
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