Broz, Pavel and Driamov, Sergey and Ziegler, Joerg and Ben-Haim, Nadav and Marsch, Stephan and Meier, Wolfgang and Hunziker, Patrick (2006) Toward intelligent nanosize bioreactors: A pH-switchable, channel-equipped, functional polymer nanocontainer. NANO LETTERS, 6 (10). pp. 2349-2353.
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Official URL: http://dx.doi.org/10.1021/nl0619305
To develop an intelligent sensor-effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4-6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.
|Subjects:||Physical Science > Nano objects|
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
|Deposited On:||22 Jan 2009 11:53|
|Last Modified:||22 Jan 2009 11:53|
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