Nano Archive

Toward intelligent nanosize bioreactors: A pH-switchable, channel-equipped, functional polymer nanocontainer

Broz, Pavel and Driamov, Sergey and Ziegler, Joerg and Ben-Haim, Nadav and Marsch, Stephan and Meier, Wolfgang and Hunziker, Patrick (2006) Toward intelligent nanosize bioreactors: A pH-switchable, channel-equipped, functional polymer nanocontainer. NANO LETTERS, 6 (10). pp. 2349-2353.

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Official URL: http://dx.doi.org/10.1021/nl0619305

Abstract

To develop an intelligent sensor-effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4-6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.

Item Type:Article
Subjects:Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:3783
Deposited By:SPI
Deposited On:22 Jan 2009 11:53
Last Modified:22 Jan 2009 11:53

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