Gao, De and Agayan, Rodney R. and Xu, Hao and Philbert, Martin A. and Kopelman, Raoul (2006) Nanoparticles for two-photon photodynamic therapy in living cells. NANO LETTERS, 6 (11). pp. 2383-2386.
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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl0617179
We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.
|Subjects:||Biomedical Science > Nanobiotechnology|
Material Science > Bio materials
|Deposited By:||Farnush Anwar|
|Deposited On:||22 Jan 2009 13:18|
|Last Modified:||22 Jan 2009 13:18|
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