Nano Archive

Nanoparticles for two-photon photodynamic therapy in living cells

Gao, De and Agayan, Rodney R. and Xu, Hao and Philbert, Martin A. and Kopelman, Raoul (2006) Nanoparticles for two-photon photodynamic therapy in living cells. NANO LETTERS, 6 (11). pp. 2383-2386.

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We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Material Science > Bio materials
ID Code:3721
Deposited By:Farnush Anwar
Deposited On:22 Jan 2009 13:18
Last Modified:22 Jan 2009 13:18

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