Gracheva, Maria E. and Xiong, A. L. and Aksimentiev, Aleksei and Schulten, K and Timp, G and Leburton, J. P. (2006) Simulation of the electric response of DNA translocation through a semiconductor nanopore-capacitor. NANOTECHNOLOGY, 17 (3). pp. 622-633.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://dx.doi.org/10.1088/0957-4484/17/3/002
A multi-scale/multi-material computational model for simulation of the electric signal detected on the electrodes of a metal-oxide-semiconductor (MOS) capacitor forming a nanoscale artificial membrane, and containing a nanopore with translocating DNA, is presented. The multi-scale approach is based on the incorporation of a molecular dynamics description of a translocating DNA molecule in the nanopore within a three-dimensional Poisson equation self-consistent scheme involving, electrolytic and semiconductor charges for the electrostatic potential calculation. The voltage signal obtained from the simulation supports the possibility for single nucleotide resolution with a nanopore device. The electric signal predicted on the capacitor electrodes complements ongoing experiments exploring the use of nanopores in a MOS capacitor membrane for DNA sequencing.
|Subjects:||Physical Science > Nanoelectronics|
Biomedical Science > Nanobiotechnology
|Deposited By:||Farnush Anwar|
|Deposited On:||22 Jan 2009 14:18|
|Last Modified:||26 Mar 2009 14:52|
Repository Staff Only: item control page