Nano Archive

Large area protein nanopatterning for biological applications

Agheli, H and Malmstrom, J and Larsson, EM and Textor, M and Sutherland, DS (2006) Large area protein nanopatterning for biological applications. NANO LETTERS, 6 (6). pp. 1165-1171.

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Large area nanopatterns of functional proteins are demonstrated. A new approach to analyze atomic force microscopy height histograms is used to quantify protein and antibody binding to nanoscale patches. Arrays of nanopatches, each containing less than 40 laminin molecules, are shown to be highly functional binding close to 1 monoclonal anti-laminin IgG (site by IKVAV sequence) or 3-4 polyclonal anti-laminin IgG's per surface bound laminin. Complementary quartz crystal microbalance measurements indicate higher functionality at nanopatches than on homogeneous surfaces.

Item Type:Article
Subjects:Analytical Science > Microscopy and probe methods
Biomedical Science > Nanobiotechnology
ID Code:3707
Deposited By:Farnush Anwar
Deposited On:22 Jan 2009 13:34
Last Modified:29 Jan 2009 13:29

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