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Conformational change induced reversible assembly/disassembly of poly-L-lysine-functionalized gold nanoparticles

Guo, Yi and Ma, Yudan and Xu, Li and Li, Jun and Yang, Wensheng (2007) Conformational change induced reversible assembly/disassembly of poly-L-lysine-functionalized gold nanoparticles. JOURNAL OF PHYSICAL CHEMISTRY C, 111 (26). pp. 9172-9176.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jp072012d

Abstract

The poly-L-lysine-functionalized gold nanoparticle (PLL-GNP) was found to undergo reversible assembly/disassembly in the range of pH from 6.5 to 11.0 at room temperature. At a high pH value, the deprotonated lysine residues allow the formation of alpha-helix and beta-sheet structures at the expense of a part of random coil and beta-turn structures, thus inducing the assembly of GNPs. With a decrease of pH to 6.5, the assembly of GNPs is disrupted due to the conversion of the alpha-helix and beta-sheet back into the random and beta-turn. It is identified that the formation/collapse of an antiparallel beta-sheet structure among PLL chains from adjacent GNPs is responsible for reversible pH-dependent assembly/disassembly of GNPs. Since the conformation-induced assembly/disassembly process of the PLL-GNP can be well recognized by a shift of the surface plasmon resonance band of the GNP and the color change of the solution, this study presents the possibility of following the conformation change of a peptide by monitoring the spectral change of the GNP.

Item Type:Article
Subjects:Material Science > Nanostructured materials
Material Science > Nanochemistry
ID Code:3560
Deposited By:Farnush Anwar
Deposited On:16 Jan 2009 13:58
Last Modified:16 Jan 2009 13:58

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