Castellana, Edward T. and Russell, David H. (2007) Tailoring nanoparticle surface chemistry to enhance laser desorption ionization of peptides and proteins. NANO LETTERS, 7 (10). pp. 3023-3025.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://pubs.acs.org/doi/abs/10.1021/nl071469w
Gold nanoparticles capped with 4-aminothiophenol have been employed for laser desorption ionization mass spectrometry of biomolecules. We demonstrate that the capped nanoparticles increase ion yields, decrease ion fragmentation, and increase the useful analyte mass range when compared to other nanoparticle systems. These results will allow for further development of nanoparticles with both targeting and enhanced ionization abilities to aid in biomarker screening.
|Subjects:||Material Science > Functional and hybrid materials|
Biomedical Science > Nanobiotechnology
|Deposited By:||Farnush Anwar|
|Deposited On:||16 Jan 2009 16:47|
|Last Modified:||29 Jan 2009 11:39|
Repository Staff Only: item control page