Nano Archive

Tailoring nanoparticle surface chemistry to enhance laser desorption ionization of peptides and proteins

Castellana, Edward T. and Russell, David H. (2007) Tailoring nanoparticle surface chemistry to enhance laser desorption ionization of peptides and proteins. NANO LETTERS, 7 (10). pp. 3023-3025.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl071469w

Abstract

Gold nanoparticles capped with 4-aminothiophenol have been employed for laser desorption ionization mass spectrometry of biomolecules. We demonstrate that the capped nanoparticles increase ion yields, decrease ion fragmentation, and increase the useful analyte mass range when compared to other nanoparticle systems. These results will allow for further development of nanoparticles with both targeting and enhanced ionization abilities to aid in biomarker screening.

Item Type:Article
Subjects:Material Science > Functional and hybrid materials
Biomedical Science > Nanobiotechnology
ID Code:3551
Deposited By:Farnush Anwar
Deposited On:16 Jan 2009 16:47
Last Modified:29 Jan 2009 11:39

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