Bora, D. K. and Deb, P (2009) Fatty Acid Binding Domain Mediated Conjugation of Ultrafine Magnetic Nanoparticles with Albumin Protein. Nanoscale Research Letters, 4 (2). pp. 138-143. ISSN 1931-7573 (Print) 1556-276X (Online)
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A novel bioconjugate of stearic acid capped maghemite nanoparticle (Î³-Fe2O3) with bovine serum albumin (BSA) was developed by taking recourse to the fatty acid binding property of the protein. From FT-IR study, it was found that conjugation took place covalently between the amine group of protein molecule and carboxyl group of stearic acid capped maghemite nanoparticle. TEM study further signified the morphology of the proposed nanobioconjuagte. The binding constant of nanoparticle with protein molecule was evaluated from the optical property studies. Also, magnetic measurement (MâH) showed retaining of magnetic property by significant values of saturation magnetization and other hysteretic parameters.
|Uncontrolled Keywords:||Bioconjugate - Maghemite nanoparticle - Bovine serum albumin - Covalent interaction - Fatty acid binding domain|
|Subjects:||Biomedical Science > Nanobiotechnology|
|Deposited By:||Lesley Tobin|
|Deposited On:||15 Jan 2009 15:41|
|Last Modified:||19 Feb 2009 17:17|
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