Nano Archive

Fatty Acid Binding Domain Mediated Conjugation of Ultrafine Magnetic Nanoparticles with Albumin Protein

Bora, D. K. and Deb, P (2009) Fatty Acid Binding Domain Mediated Conjugation of Ultrafine Magnetic Nanoparticles with Albumin Protein. Nanoscale Research Letters, 4 (2). pp. 138-143. ISSN 1931-7573 (Print) 1556-276X (Online)

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Official URL: http://www.springerlink.com/content/v02mx225706422...

Abstract

A novel bioconjugate of stearic acid capped maghemite nanoparticle (γ-Fe2O3) with bovine serum albumin (BSA) was developed by taking recourse to the fatty acid binding property of the protein. From FT-IR study, it was found that conjugation took place covalently between the amine group of protein molecule and carboxyl group of stearic acid capped maghemite nanoparticle. TEM study further signified the morphology of the proposed nanobioconjuagte. The binding constant of nanoparticle with protein molecule was evaluated from the optical property studies. Also, magnetic measurement (M–H) showed retaining of magnetic property by significant values of saturation magnetization and other hysteretic parameters.

Item Type:Article
Uncontrolled Keywords:Bioconjugate - Maghemite nanoparticle - Bovine serum albumin - Covalent interaction - Fatty acid binding domain
Subjects:Biomedical Science > Nanobiotechnology
ID Code:3406
Deposited By:Lesley Tobin
Deposited On:15 Jan 2009 15:41
Last Modified:19 Feb 2009 17:17

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