Nano Archive

Multi-functional chitosan nanoparticles encapsulating quantum dots and Gd-DTPA as imaging probes for bio-applications

Tan, Wee Beng and Zhang, Yong (2007) Multi-functional chitosan nanoparticles encapsulating quantum dots and Gd-DTPA as imaging probes for bio-applications. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 7 (7). pp. 2389-2393.

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Official URL: http://www.springerlink.com/content/57x324172qq208...

Abstract

Chitosan was used to encapsulate both CdSe/ZnS quantum dots (QDs) and the magnetic resonance imaging (MRI) contrast agent gadolinium-diethylenetriaminepentaacetate (Gd-DTPA), forming multi-functional nanoparticles that can be used in a wide range of in vitro or in vivo studies as fluorescent biological labels as well as MRI contrast agents, respectively. Multi-color QDs at pre-determined molar ratios were encapsulated into chitosan nanoparticles to produce bar-coding fluorescent labels. The encapsulated QDs and Gd-DTPA still maintained their desirable optical properties and relatively high relaxivity, respectively. The chitosan nanoparticles also showed good aqueous stability and enhanced biocompatibility on myoblast cells.

Item Type:Article
Uncontrolled Keywords:chitosan; nanoparticle; quantum dot; Gd-DTPA; fluorescent; magnetic
Subjects:Material Science > Functional and hybrid materials
Biomedical Science > Nanobiotechnology
ID Code:3269
Deposited By:Farnush Anwar
Deposited On:15 Jan 2009 12:36
Last Modified:28 Jan 2009 15:35

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