Nano Archive

Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging

Kobayashi, Hisataka and Koyama, Yoshinori and Barrett, Tristan and Hama, Yukihiro and Regino, Celeste A. S. and Shin, In Soo and Jang, Beom-Su and Le, Nhat and Paik, Chang H. and Choyke, Peter L. and Urano, Yasuteru (2007) Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging. ACS NANO, 1 (4). pp. 258-264.

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Current contrast agents generally have one function and (an only be imaged in monochrome; therefore, the majority of imaging methods can only impart uniparametric information. A single nanoparticle has the potential to be loaded with multiple payloads. Such multimodality probes have the ability to be imaged by more than one imaging technique, which could compensate for the weakness or even combine the advantages of each individual modality. Furthermore, optical imaging using different optical probes enables us to achieve multicolor in vivo imaging, wherein multiple parameters can be read from a single image. To allow differentiation of multiple optical signals in vivo, each probe should have a close but different near-infrared emission. To this end, we synthesized nanoprobes with multimodal and multicolor potential, which employed a polyamidoamine dendrimer platform linked to both radionuclides and optical probes, permitting dual-modality scintigraphic and five-color near-infrared optical lymphatic imaging using a multiple-excitation spectrally resolved fluorescence imaging technique.

Item Type:Article
Uncontrolled Keywords:dendrimer; scintigraphy; near-infrared; fluorescence imaging; multiple modalities; multiple colors; lymphatic imaging
Subjects:Analytical Science > Microscopy and probe methods
Material Science > Functional and hybrid materials
ID Code:3257
Deposited By:Farnush Anwar
Deposited On:16 Jan 2009 11:24
Last Modified:29 Jan 2009 10:07

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