Wang, Joseph and Tangkuaram, Tanin and Loyprasert, Suchera and Vazquez-Alvarez, Terannie and Veerasai, Waret and Kanatharana, Proespichaya and Thavarungkul, Panote (2007) Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes. ANALYTICA CHIMICA ACTA, 581 (1). pp. 1-6.
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Official URL: http://dx.doi.org/10.1016/j.aca.2006.07.084
A bilayer surface coating, prepared by electrodepositing ruthenium oxide (RuOx) onto a carbon nanotube (CNT) layer, offers dramatic improvements in the stability and sensitivity of voltammetric and amperometric measurements of insulin compared to the individual (CNT or RuOx) coated electrodes. The enhanced electrocatalytic activity towards insulin is indicated from lowering the potential of the oxidation process (starting around 0.35 versus Ag/AgCl) and the substantially higher sensitivity over the entire potential range. A wide linear dynamic range (10-800 nM) was achieved with a detection limit of I nM. The marked electrocatalytic activity of the RuOx/CNT coating towards insulin is coupled with a greatly enhanced stability. For example, the insulin amperometric response of the RuOx/CNT-coated electrodes is highly stable, with 97% of the initial activity remaining after 60 min stirring of 2 x 10(-6) M solution (compared to significantly faster current diminutions at the RuOx- or CNT-coated surfaces). The results suggest great promise for miniaturized sensors and detectors for monitoring insulin. (c) 2006 Elsevier B.V. All rights reserved.
|Uncontrolled Keywords:||insulin; electrocatalysis; carbon nanotubes; ruthenium|
|Subjects:||Material Science > Functional and hybrid materials|
Analytical Science > Nanotechnology for sensing and actuating
Material Science > Nanostructured materials
Biomedical Science > Nanomedicine
|Deposited By:||Anuj Seth|
|Deposited On:||13 Jan 2009 17:22|
|Last Modified:||20 Jan 2009 15:52|
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