Joshi, Amit and Punyani, Supriya and Bale, Shyam Sundhar and Yang, Hoichang and Borca-Tasciuc, Theodorian and Kane, Ravi S. (2008) Nanotube-assisted protein deactivation. NATURE NANOTECHNOLOGY, 3 (1). pp. 41-45.
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Official URL: http://www.nature.com/nnano/journal/v3/n1/abs/nnan...
Conjugating proteins onto carbon nanotubes has numerous applications in biosensing(1,2), imaging and cellular delivery(3-5). However, remotely controlling the activity of proteins in these conjugates has never been demonstrated. Here we show that upon near-infrared irradiation, carbon nanotubes mediate the selective deactivation of proteins in situ by photochemical effects. We designed nanotube-peptide conjugates to selectively destroy the anthrax toxin, and also optically transparent coatings that can self-clean following either visible or near-infrared irradiation. Nanotube-assisted protein deactivation may be broadly applicable to the selective destruction of pathogens and cells, and will have applications ranging from antifouling coatings to functional proteomics.
|Subjects:||Physical Science > Nano objects|
Biomedical Science > Nanobiotechnology
Material Science > Bio materials
Biomedical Science > Nanotechnology for human health
|Deposited By:||Anuj Seth|
|Deposited On:||12 Jan 2009 13:54|
|Last Modified:||20 Jan 2009 12:10|
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