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Effects of hydrated forms of C-60 fullerene on amyloid beta-peptide fibrillization in vitro and performance of the cognitive task

Podolski, I. Ya. and Podlubnaya, Z. A. and Kosenko, E. A. and Mugantseva, E. A. and Makarova, E. G. and Marsagishvili, L. G. and Shpagina, M. D. and Kaminsky, Yu. G. and Andrievsky, G. V. and Klochkov, V. K. (2007) Effects of hydrated forms of C-60 fullerene on amyloid beta-peptide fibrillization in vitro and performance of the cognitive task. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 7 (4-5). pp. 1479-1485.

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Official URL: http://www.ingentaconnect.com/asp/jnn/2007/0000000...

Abstract

It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C-60 inhibited the fibrillization of amyloid-beta(25-35) peptide. The fullerene affected the amyloid-beta(25-35) assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C-60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C-60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-beta(25-35) (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.

Item Type:Article
Uncontrolled Keywords:hydrated C-60 fullerene; amyloid beta-peptide fibrillization; Alzheimer's disease; animal model; hippocampus; cognitive tasks
Subjects:Analytical Science > Microscopy and probe methods
Material Science > Functional and hybrid materials
Biomedical Science > Nanomedicine
ID Code:2800
Deposited By:Farnush Anwar
Deposited On:13 Jan 2009 16:21
Last Modified:27 Jan 2009 11:54

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