Nano Archive

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Nasongkla, Norased and Bey, Erik and Ren, Jimin and Ai, Hua and Khemtong, Chalermchai and Guthi, Jagadeesh Setti and Chin, Shook-Fong and Sherry, A. Dean and Boothman, David A. and Gao, Jinming (2006) Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. NANO LETTERS, 6 (11). pp. 2427-2430.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl061412u

Abstract

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide ( SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:2743
Deposited By:Lesley Tobin
Deposited On:19 Jan 2009 15:24
Last Modified:19 Jan 2009 15:24

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