Nano Archive

Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe

Mulder, W. J. M. and Koole, R and Brandwijk, R. J. and Storm, G and Chin, Patrick T. K. and Strijkers, G. J. and Donega, C. D. and Nicolay, K and Griffioen, A. W. (2006) Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. NANO LETTERS, 6 (1). pp. 1-6.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl051935m

Abstract

MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alpha v/beta 3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.

Item Type:Article
Subjects:Analytical Science > Microscopy and probe methods
Biomedical Science > Nanomedicine
ID Code:2737
Deposited By:Lesley Tobin
Deposited On:20 Jan 2009 12:00
Last Modified:19 Feb 2009 10:10

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