Mulder, W. J. M. and Koole, R and Brandwijk, R. J. and Storm, G and Chin, Patrick T. K. and Strijkers, G. J. and Donega, C. D. and Nicolay, K and Griffioen, A. W. (2006) Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. NANO LETTERS, 6 (1). pp. 1-6.
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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl051935m
MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alpha v/beta 3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.
|Subjects:||Analytical Science > Microscopy and probe methods|
Biomedical Science > Nanomedicine
|Deposited By:||Lesley Tobin|
|Deposited On:||20 Jan 2009 12:00|
|Last Modified:||19 Feb 2009 10:10|
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