Nano Archive

Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells

Chithrani, B. D. and Ghazani, A. A. and Chan, Warren C. W. (2006) Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. NANO LETTERS, 6 (4). pp. 662-668.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl052396o

Abstract

We investigated the intracellular uptake of different sized and shaped colloidal gold nanoparticles. We showed that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles (e.g., uptake half-life of 14, 50, and 74 nm nanoparticles is 2.10, 1.90, and 2.24 h, respectively). The findings from this study will have implications in the chemical design of nanostructures for biomedical applications (e.g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics).

Item Type:Article
Subjects:Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanobiotechnology
ID Code:2731
Deposited By:Lesley Tobin
Deposited On:20 Jan 2009 12:49
Last Modified:19 Feb 2009 09:09

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