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High-density targeting of a viral multifunctional nanoplatform to a pathogenic, biofilm-forming bacterium

Suci, Peter A. and Berglund, Deborah L. and Liepold, Lars and Brumfield, Susan and Pitts, Betsey and Davison, Willy and Oltrogge, Luke and Hoyt, Kathryn O. and Codd, Sarah and Stewart, Philip S. and Young, Mark and Douglas, Trevor (2007) High-density targeting of a viral multifunctional nanoplatform to a pathogenic, biofilm-forming bacterium. CHEMISTRY & BIOLOGY, 14 (4). pp. 387-398.

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Official URL: http://www.cell.com/chemistry-biology/abstract/S10...

Abstract

Nanomedicine directed at diagnosis and treatment of infections can benefit from innovations that have substantially increased the variety of available multifunctional nanoplatforms. Here, we targeted a spherical, icosahedral viral nanoplatform to a pathogenic, biofilm-forming bacterium, Staphylococcus aureus. Density of binding mediated through specific protein-ligand interactions exceeded the density expected for a planar, hexagonally close-packed array. A multifunctionalized viral protein cage was used to load imaging agents (fluorophore and MRI contrast agent) onto cells. The fluorescence-imaging capability allowed for direct observation of penetration of the nanoplatform into an S. aureus biofilm. These results demonstrate that multifunctional nanoplatforms based on protein cage architectures have significant potential as tools for both diagnosis and targeted treatment of recalcitrant bacterial infections.

Item Type:Article
Subjects:Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:2720
Deposited By:Farnush Anwar
Deposited On:07 Jan 2009 16:59
Last Modified:22 Jan 2009 12:21

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