Nano Archive

Inhalable liposomal formulation for vasoactive intestinal peptide

Hajos, Franz and Stark, Brigitte and Hensler, Sigrid and Prassl, Ruth and Mosgoeller, Wilhelm (2008) Inhalable liposomal formulation for vasoactive intestinal peptide. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 357 (1-2). pp. 286-294.

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Official URL: http://dx.doi.org/10.1016/j.ijpharm.2008.01.046

Abstract

Inhalation of vasoactive intestinal peptide (VIP) was suggested as promising treatment option of various lung diseases like asthma and pulmonary hypertension. However, the medical use of peptides is limited by their short half-life due to rapid enzymatic degradation in the airways. For that reason, we recently developed unilamellar nano-sized VIP-loaded liposomes (VLL). Now we investigated their applicability for inhalation purposes. After nebulisation by a mouthpiece ventilation inhaler we found the particle size almost unaffected, being in a size range appropriate for bronchiolar deposition; we observed no peptide release due to nebulisation. The VIP release kinetics from VLL were tested by an ex vivo vasorelaxation model. Exposure to target organs revealed an immediate response, which was significantly retarded for VLL as compared to free VIP (p = 0.001). Using vasorelaxation as endpoint, we observed a sustained release and an extended pharmacological effect compared to equimolar free VIP. The liposomes have the potential to improve VIP inhalation therapy by providing a ``dispersible peptide depot'' in the bronchi. Thereby, the release of VIP from liposomes may be triggered by exposure to cells, i.e. directly by ligand-receptor interactions. (c) 2008 Elsevier B.V. All rights reserved.

Item Type:Article
Uncontrolled Keywords:nanomedicine; liposome; drug inhalation; VIP inhalation
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:2701
Deposited By:Farnush Anwar
Deposited On:07 Jan 2009 17:14
Last Modified:07 Jan 2009 17:14

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