Nano Archive

Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles

Giljohann, David A. and Seferos, Dwight S. and Patel, Pinal C. and Millstone, Jill E. and Rosi, Nathaniel L. and Mirkin, Chad A. (2007) Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. NANO LETTERS, 7 (12). pp. 3818-3821.

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Official URL: http://dx.doi.org/10.1021/nl072471q

Abstract

The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated Ali the particle.

Item Type:Article
Subjects:Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
ID Code:2673
Deposited By:Anuj Seth
Deposited On:09 Jan 2009 09:51
Last Modified:20 Jan 2009 11:06

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