Giljohann, David A. and Seferos, Dwight S. and Patel, Pinal C. and Millstone, Jill E. and Rosi, Nathaniel L. and Mirkin, Chad A. (2007) Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. NANO LETTERS, 7 (12). pp. 3818-3821.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://dx.doi.org/10.1021/nl072471q
Abstract
The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated Ali the particle.
| Item Type: | Article |
|---|---|
| Subjects: | Physical Science > Nano objects Biomedical Science > Nanobiotechnology Material Science > Nanochemistry |
| ID Code: | 2673 |
| Deposited By: | Anuj Seth |
| Deposited On: | 09 Jan 2009 09:51 |
| Last Modified: | 20 Jan 2009 11:06 |
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