Choi, Mi-Ran and Stanton-Maxey, Katie J. and Stanley, Jennifer K. and Levin, Carly S. and Bardhan, Rizia and Akin, Demir and Badve, Sunil and Sturgis, Jennifer. and Robinson, J. Paul and Bashir, Rashid and Halas, Naomi J. and Clare, Susan E. (2007) A cellular Trojan horse for delivery of therapeutic nanoparticles into tumors. NANO LETTERS, 7 (12). pp. 3759-3765.
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Official URL: http://dx.doi.org/10.1021/nl072209h
Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as ``Trojan Horses'' for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.
|Subjects:||Physical Science > Nano objects|
Biomedical Science > Nanomedicine
|Deposited By:||Anuj Seth|
|Deposited On:||09 Jan 2009 09:58|
|Last Modified:||20 Jan 2009 11:10|
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