Nano Archive

Self-assembled virus-like particles with magnetic cores

Huang, Xinlei and Bronstein, Lyudmila M. and Retrum, John and Dufort, Chris and Tsvetkova, Irina and Aniagyei, Stella and Stein, Barry and Stucky, Galen and McKenna, Brandon and Remmes, Nicholas and Baxter, David and Kao, C. Cheng and Dragnea, Bogdan (2007) Self-assembled virus-like particles with magnetic cores. NANO LETTERS, 7 (8). pp. 2407-2416.

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Efficient encapsulation of functionalized spherical nanoparticles by viral protein cages was found to occur even if the nanoparticle is larger than the inner cavity of the native capsid. This result raises the intriguing possibility of reprogramming the self-assembly of viral structural proteins. The iron oxide nanotemplates used in this work are superparamagnetic, with a blocking temperature of about 250 K, making these virus-like particles interesting for applications such as magnetic resonance imaging and biomagnetic materials. Another novel feature of the virus-like particle assembly described in this work is the use of an anionic lipid micelle coat instead of a molecular layer covalently bound to the inorganic nanotemplate. Differences between the two functionalization strategies are discussed.

Item Type:Article
Subjects:Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Physical Science > Nanomagnetics
ID Code:2638
Deposited By:Anuj Seth
Deposited On:09 Jan 2009 13:34
Last Modified:20 Jan 2009 11:21

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