Nano Archive

Silver nanoparticle-oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties

Lee, Jae-Seung and Lytton-Jean, Abigail K. R. and Hurst, Sarah J. and Mirkin, Chad A. (2007) Silver nanoparticle-oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties. NANO LETTERS, 7 (7). pp. 2112-2115.

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We report a new strategy for preparing silver nanoparticle-oligonucleotide conjugates that are based upon DNA with cyclic disulfide-anchoring groups. These particles are extremely stable and can withstand NaCl concentrations up to 1.0 M. When silver nanoparticles functionalized with complementary sequences are combined, they assemble to form DNA-linked nanoparticle networks. This assembly process is reversible with heating and is associated with a red shifting of the particle surface plasmon resonance and a concomitant color change from yellow to pale red. Analogous to the oligonucleotide-functionalized gold nanoparticles, these particles also exhibit highly cooperative binding properties with extremely sharp melting transitions. This work is an important step toward using silver nanoparticle-oligonucleotide conjugates for a variety of purposes, including molecular diagnostic labels, synthons in programmable materials synthesis approaches, and functional components for nanoelectronic and plasmonic devices.

Item Type:Article
Subjects:Material Science > Nanofabrication processes and tools
Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
ID Code:2616
Deposited By:Anuj Seth
Deposited On:09 Jan 2009 15:40
Last Modified:20 Jan 2009 11:32

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