Nano Archive

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

Prinzen, Lenneke and Miserus, Robbert-Jan J. H. M. and Dirksen, Anouk and Hackeng, Tilman M. and Deckers, Niko and Bitsch, Nicole J. and Megens, Remco T. A. and Douma, Kim and Heemskerk, Johan W. and Kooi, M. Eline and Frederik, Peter M. and Slaaf, Dick W. and van Zandvoort, Marc A. M. J. and Reutelingsperger, Chris P. M. (2007) Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. NANO LETTERS, 7 (1). pp. 93-100.

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Official URL: http://dx.doi.org/10.1021/nl062226r

Abstract

A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r(1)) of 3000-4500 mM(-1) s(-1) per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies.

Item Type:Article
Subjects:Physical Science > Nanophysics
Physical Science > Nano objects
Biomedical Science > Nanomedicine
ID Code:2601
Deposited By:Anuj Seth
Deposited On:09 Jan 2009 16:54
Last Modified:20 Jan 2009 11:45

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