Nano Archive

Toward reliable algorithmic self-assembly of DNA tiles: A fixed-width cellular automaton pattern

Fujibayashi, Kenichi and Hariadi, Rizal and Park, Sung Ha and Winfree, Erik and Murata, Satoshi (2008) Toward reliable algorithmic self-assembly of DNA tiles: A fixed-width cellular automaton pattern. NANO LETTERS, 8 (7). pp. 1791-1797.

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Official URL: http://dx.doi.org/10.1021/nl0722830

Abstract

Bottom-up fabrication of nanoscale structures relies on chemical processes to direct, self-assembly. The complexity, precision, and yield achievable by a one-pot reaction are limited by our ability to encode assembly instructions into the molecules themselves. Nucleic acids provide a platform for investigating these issues, as molecular structure and intramolecular interactions can encode growth rules. Here, we use DNA tiles and DNA origami to grow crystals containing a cellular automaton pattern. In a one-pot annealing reaction, 250 DNA strands first assemble into a set of 10 free tile types and a seed structure, then the free tiles grow algorithmically from the seed according to the automaton rules. In our experiments, crystals grew to similar to 300 nm long, containing similar to 300 tiles with an initial assembly error rate of similar to 1.4% per tile. This work provides evidence that programmable molecular self-assembly may be sufficient to create a wide range of complex objects in one-pot reactions.

Item Type:Article
Subjects:Material Science > Nanofabrication processes and tools
Biomedical Science > Nanobiotechnology
Material Science > Nanostructured materials
ID Code:2378
Deposited By:Anuj Seth
Deposited On:17 Dec 2008 13:51
Last Modified:17 Dec 2008 13:51

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