Nano Archive

Coupling ion channels to receptors for biomolecule sensing

Moreau, Christophe J. and Dupuis, Julien P. and Revilloud, Jean and Arumugam, Karthik and Vivaudou, Michel (2008) Coupling ion channels to receptors for biomolecule sensing. NATURE NANOTECHNOLOGY, 3 (10). pp. 620-625.

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Nanoscale electrical biosensors are promising tools for diagnostics and high-throughput screening systems. The electrical signal allows label-free assays with a high signal-to-noise ratio and fast real-time measurements. The challenge in developing such biosensors lies in functionally connecting a molecule detector to an electrical switch. Advances in this field have relied on synthetic ion-conducting pores(1) and modified ion channels(2-4) that are not yet suitable for biomolecule screening. Here we report the design and characterization of a novel bioelectric-sensing platform engineered by coupling an ion channel, which serves as the electrical probe, to G-protein-coupled receptors (GPCRs), a family of receptors that detect molecules outside the cell. These ion-channel-coupled receptors may potentially detect a wide range of ligands recognized by natural or altered GPCRs(5,6), which are known to be major pharmaceutical targets(7). This could form a unique platform for label-free drug screening(8).

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanobiotechnology
Material Science > Nanostructured materials
Biomedical Science > Nanomedicine
ID Code:2371
Deposited By:Anuj Seth
Deposited On:17 Dec 2008 14:35
Last Modified:19 Jan 2009 14:11

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