Nano Archive

Herding nanotransporters: Localized activation via release and sequestration of control molecules

Tucker, Robert and Katira, Parag and Hess, Henry (2008) Herding nanotransporters: Localized activation via release and sequestration of control molecules. NANO LETTERS, 8 (1). pp. 221-226.

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Official URL: http://dx.doi.org/10.1021/nl072516n

Abstract

A challenge for nanotechnology is the dynamic and specific control of nanomachines by the user. Molecular shuttles, consisting of cargo-binding microtubules propelled by surface-immobilized kinesin motor proteins, are an example of a nanoscale system that ideally can be selectively activated at programmable locations and times. Here we discuss a biomimetic solution where activating molecules are delivered locally via photolysis of a caged compound and subsequently sequestered in an enzymatic network. The controlled sequestration of the activator not only creates a rapid deactivation when the stimulus is removed but also sharpens the concentration profile of the rapidly diffusing activator. This improvement comes at the expense of a reduced efficiency in the utilization of the activator molecules, suggesting that these nanosystems are most efficiently addressed as a swarm rather than as individuals. Our work represents a step toward transferring the cellular control strategies of molecular activation to bionanotechnology.

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
ID Code:2359
Deposited By:Anuj Seth
Deposited On:17 Dec 2008 16:01
Last Modified:19 Jan 2009 14:34

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