Nano Archive

Interaction of nanoparticles with lipid membrane

Roiter, Yuri and Ornatska, Maryna and Rammohan, Aravind R. and Balakrishnan, Jitendra and Heine, David R. and Minko, Sergiy (2008) Interaction of nanoparticles with lipid membrane. NANO LETTERS, 8 (3). pp. 941-944.

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A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the L-alpha-dimyristoyl phosphatidylcholine membrane around 1.2-22 nm polar nanoparticles deposited on mica surface. Lipid bilayer envelops or closely follows surface features with the curvatures outside of that region. This finding provides essential information for the understanding of nanoparticle-lipid membrane interaction, cytotoxicity, preparation of biomolecular templates and supported lipid membranes on rough and patterned surfaces.

Item Type:Article
Subjects:Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
ID Code:2351
Deposited By:Anuj Seth
Deposited On:17 Dec 2008 17:15
Last Modified:20 Jan 2009 10:36

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