Nano Archive

Nanoparticle-mediated cellular response is size-dependent

Jiang, Wen and Kim, Betty Y. S. and Rutka, James T. and Chan, Warren C. W. (2008) Nanoparticle-mediated cellular response is size-dependent. NATURE NANOTECHNOLOGY, 3 (3). pp. 145-150.

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Official URL: http://www.nature.com/nnano/journal/v3/n3/abs/nnan...

Abstract

Nanostructures of different sizes, shapes and material properties have many applications in biomedical imaging, clinical diagnostics and therapeutics(1-6). In spite of what has been achieved so far, a complete understanding of how cells interact with nanostructures of well-defined sizes, at the molecular level, remains poorly understood. Here we show that gold and silver nanoparticles coated with antibodies can regulate the process of membrane receptor internalization. The binding and activation of membrane receptors and subsequent protein expression strongly depend on nanoparticle size. Although all nanoparticles within the 2-100 nm size range were found to alter signalling processes essential for basic cell functions ( including cell death) 7, 40- and 50-nm nanoparticles demonstrated the greatest effect. These results show that nanoparticles should no longer be viewed as simple carriers for biomedical applications, but can also play an active role in mediating biological effects. The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity.

Item Type:Article
Subjects:Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:2309
Deposited By:Anuj Seth
Deposited On:18 Dec 2008 16:05
Last Modified:19 Jan 2009 15:15

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