Nano Archive

Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression

Kong, Hyun Joon and Hsiong, Susan and Mooney, David J. (2007) Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. NANO LETTERS, 7 (1). pp. 161-166.

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Official URL: http://dx.doi.org/10.1021/nl062485g

Abstract

It is hypothesized that the nanoscale organization of cell adhesion ligands in a synthetic ECM regulates nonviral gene delivery. This hypothesis was examined with pre-osteoblasts cultured on substrates which present varied density and spacing of synthetic adhesion ligands. The levels of gene transfer and expression were increased with the density of adhesion ligands, but decreased with the spacing of ligands, due to changes in the cell growth rate. This study provides a material-based control point on the nanometer scale for nonviral gene based therapies.

Item Type:Article
Subjects:Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:2294
Deposited By:Anuj Seth
Deposited On:18 Dec 2008 17:01
Last Modified:19 Jan 2009 15:45

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