Wang, Xuhua and Hofmann, Oliver and Das, Rupa and Barrett, Edward M. and deMello, Andrew J, and deMello, John C. and Bradley, Donald C. (2007) Integrated thin-film polymer/fullerene photodetectors for on-chip microfluidic chemiluminescence detection. LAB ON A CHIP, 7 (1). pp. 58-63. ISSN 1473-0197 (Print); 1473-0189 (Electronic)
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We report the use of solution-processed thin-film organic photodiodes for microscale chemiluminescence. The active layer of the photodiodes comprised a 1 : 1 blend by weight of the conjugated polymer poly(3-hexylthiophene) [P3HT] and [6,6]-phenyl-C-61-butyric acid-methylester [PCBM]-a soluble derivative of C-60. The devices had an active area of 1 mm x 1 mm, and a broad-band response from 350 to 700 nm, with an external quantum efficiency of more than 50% between 450 and 550 nm. The photodiodes have a simple layered structure that permits facile integration with planar chip-based systems. To evaluate the suitability of the organic devices as integrated detectors for microscale chemiluminescence, a peroxyoxalate based chemiluminescence reaction (PO-CL) was monitored within a poly(dimethyl-siloxane) (PDMS) microfluidic device. Quantitation of hydrogen peroxide indicated excellent linearity and yielded a detection limit of 10 mu M, comparable with previously reported results using micromachined silicon microfluidic chips with integrated silicon photodiodes. The combination of organic photodiodes with PDMS microfluidic chips offers a means of creating compact, sensitive and potentially low-cost microscale CL devices with wide-ranging applications in chemical and biological analysis and clinical diagnostics.
|Subjects:||Biomedical Science > Nanobiotechnology|
|Deposited By:||M T V|
|Deposited On:||17 Dec 2008 16:00|
|Last Modified:||17 Dec 2008 16:00|
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